Showing posts with label history. Show all posts
Showing posts with label history. Show all posts

Apr 20, 2010

"Hope he's only a Sunday creationist" by G. Trudeau


Cartoon by Garry Trudeau

This comic strip by Garry Trudeau was published in 2006, so you may already know it. Here, a doctor offers two antibiotic choices to a patient suffering from tuberculosis (TB). The choice appears to depend on the patient's religious beliefs. I hope the patient chose wisely -- for his own benefit and for that of all the people that could be otherwise infected by his spreading of TB microbes.


Edward Trudeau stamp
Interestingly, cartoonist Garry Trudeau is the great-grandson of Dr. Edward Trudeau, who founded the Adirondack Cottage Sanitarium for the treatment of pulmonary TB, at Saranac Lake, New York State, in 1884. It was found at the time that tuberculous patients greatly benefited from a "rest cure" that included lots of mountain fresh air, and good nutrition. The sanatorium was later renamed and reorganized as a biomedical research center. Known today as the Trudeau Institute, it is devoted to researching our immune system to find better ways of preventing and treating human diseases, including TB, influenza, tropical diseases and cancer.



Credits for images:
- Cartoon:
Author: Garry Trudeau (Doonesbury.com). Source: GoComics.
- Stamp:
United States Postal Service. Stamp designed by Howard E. Paine and created by Mark Summers, based on a photograph of Dr. Trudeau provided by the American Lung Association. Source: The Stamp Collecting Round-up. See also a press release at EurekAlert.


Hat tip:
Comunicar ciencia con humor [in Spanish] by José Pardina, Asociación Española de Comunicación Científica (AECC) [Spanish Association for Science Communication].

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Mar 8, 2010

Edward Jenner and Joseph Lister, posted

British stamps (2010) featuring Edward Jenner and Joseph Lister
A few days ago, the UK postal service issued a new series of stamps featuring 10 eminent scientists to celebrate the 350th anniversary of the Royal Society. The image above shows two of the stamps, depicting Edward Jennner (1749-1823) and Joseph Lister (1827-1912) -- who are considered the 'fathers' of vaccination and antiseptic surgery, respectively. They both had a rough time trying to convince their fellow physicians to accept their proposed methods as good and useful practices. But they eventually succeeded, and millions of lives were saved.

Jenner's development of smallpox vaccine stampIt is noteworthy that Jenner was elected a fellow of the Royal Society in 1789 thanks to his research on cuckoos (the birds, not the clocks). He was a 'natural scientist' and studied a variety of issues ranging from fossils to animal behaviour, and from balloons to medicine. It was in 1796 when he carried out his famous experiments, showing that people could be protected against the deadly smallpox by inoculating them with cowpox (a mild, related disease). Although the basic rationale behind Jenner's technique was not novel (but this was not the reason why the Royal Society rejected his original report!), his careful studies and his tenacity were fundamental for a wide progressive adoption of vaccination. Now --two centuries later-- the world can celebrate the 30th anniversary of smallpox eradication. This deserves a stamp or two, doesn't it?

Lister centennary stamp (1965)Now, let's turn our look to Joseph Lister. He introduced phenol (carbolic acid) to sterilise surgical instruments and to clean wounds. As a result, post-operative infections were greatly reduced, and many lives (and body parts that otherwise would be amputated) were saved. Because of these achievements, Lister was not only elected fellow but president of the Royal Society (between 1895 and 1900), and his name was given to a bacterium ...and a mouthwash (what an honour!).

Anyway, it seems that there was some kind of infectious hunger for 'small knowledge' at the Listers' house, as Joseph was not the only one interested in the microscopic world. His father, Joseph Jackson Lister (1786-1869), made crucial advances toward correcting image aberrations in microscopes (and he was elected fellow of the Royal Society in 1832). After his work, the improved microscopes became powerful instruments, allowing more detailed observations of specimens and, hence, the birth of modern histology.

Now this may not come as a surprise to you, but (at least) two other members of the family were also elected fellows of the Royal Society. They were Arthur Lister (1830-1908, Joseph's brother) and Gulielma Lister (1860-1949, Arthur's daughter). Arthur and Gulielma became renowned botanists and mycologists, and world experts in mycetozoa (myxomycetes, slime molds). I'm wondering if they started by playing with J.J.'s old microscope? Gulielma's achievements are especially remarkable in a time (early 1900's) when very very few women were allowed to excel in science: she was a founding member of the British Mycological Society (and president in two occasions), as well as fellow, council member and vice-president of the Linnaean Society. Does anybody know of a stamp featuring Gulielma? Probably not (yet) but this could be a good topic for the next International Women's Day...


Further reading:

Stamps commemorating the Royal Society anniversary:
- Getting the Royal Society stamp of approval by Charlotte King. New Scientist, 25 Feb 2010. It includes large-size images of the 10 stamps.
- The Royal Society 350 Years, British Postal Museum & Archive.
- Science stamps mark the Royal Society's 350th anniversary, Royal Society, 24 Feb 2010.
- 350th Anniversary of the Royal Society, new Great Britain stamps, Norvic Philatelics. Includes interesting technical details and image credits, and a few special postmarks.

Edward Jenner and smallpox:
- Edward Jenner Museum, Gloucestershire, UK. Excellent website with plenty of information.
- Edward Jenner and the history of smallpox and vaccination by Stefan Riedel, Proc (Bayl Univ Med Cent) (2005) 18, 21–25.
- Edward Jenner (1749-1823), historical figures, BBC.
- Smallpox, World Health Organization.

Joseph Lister and his relatives:
- Joseph Lister: Surgery Transformed, a video produced by British Medical Journal Media.
- Joseph Jackson Lister (1786-1869), Pioneers in Optics. Science Optics & You, Molecular Expressions.
- Early Myxomycetologists (including Arthur and Gulielma Lister), Myxoweb.
- Gulielma Lister (1860-1949), biography, Wanstead Wildlife.
- Biography of Gulielma Lister (1860-1949), The Biographical Dictionary of Women in Science: L-Z. By Marilyn Bailey Ogilvie, Joy Dorothy Harvey.

Microbiology (and other sciences) featured on stamps:
- Microscopy on stamps by Dave Walker, Microscopy-UK. Great article, together with the following one:
- Photomicrography on stamps by Dave Walker, Microscopy-UK.
- Physics-related stamps, compiled by Joachim Reinhardt. Mostly about physicists, but there are also a few other scientists, mathematicians and engineers (including Antonie van Leeuwenhoek and Robert Hooke).
- Science and Technology on Stamps, A to Zee ("the web guide for collectors").
- Sci-Philately: a Selective History of Science on Stamps by Maiken Naylor, University at Buffalo Libraries.
- Medical Stamps, Scientific-web.com
- Filatelia Médica - Medical Stamps by Dr Tuoto.
- Pasteur on Stamps by Dr Tuoto.
- AIDS on Stamps.
- Malaria on Stamps Collection.
- Collect GB Stamps, resources for collecting British stamps. It has a good search tool.

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Jan 26, 2010

Great microbiologists - a brickfilm

A long time ago I added a video bar on the side of my blog (only on main page), under the following title: "Microbial" videos (live search). The thing uses some microbial-related terms to automatically retrieve videos from YouTube, Google Videos and the like. This way I found a very nice "brickfilm" that is displayed below. The brickfilm (a stop-motion animation using LEGO or other brick-like elements) is called Great microbiologists and takes a funny look at microbiology and its early history. It was made in 2006 to commemorate the graduation of two students from the Microbiology department at Colorado State University. I hope you enjoy the video as much as I do.




Notes and related links:

- About the video bar: "Microbial" videos (live search)
The video bar is only visible on the main page of my blog, not on individual posts. It uses a Google AJAX Search API (whatever this may be) that can be found at Video Bar Wizard. You can use this "wizard" to add a similar video bar to your blog and display either a live search (as I did) or a set of selected channels. Of course, the automated search may retrieve both relevant and totally irrelevant videos, depending on your choice of search terms.

- About the brickfilm "Great microbiologists"

Watch the video at YouTube
Read more information and download the film at Brickfilms.com

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Nov 15, 2009

Microbes and infectious disease, 50 years ago

The following videos are short educational films made in the 1940s and 1950s and provide some basic knowledge on infectious diseases and microbiology. How much has this basic knowledge changed after half a century? Which specific statements in the videos should be changed (and why) if you wanted these films to comply with today's microbiology? Please leave any comments here.

Video no. 1: Bacteria footage (AVG-BF231) [on bacterial biology]




Video no. 2: Insects As Carriers of Disease (1945) [a Disney film]




Video no. 3: Outbreak of Salmonella Infection (1954)




The three videos were uploaded onto Google Video by A/V Geeks. They have been digitizing thousands of TV commercials held at Duke University’s Hartman Center for Advertising.

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May 5, 2008

Charlton Heston: the connection

Charlton Heston in The Ten CommandmentsNow I am explaining the connection between Charlton Heston and actinomycetes. It is indeed a very simple link, as you will see.

As a boy, Charlton Heston was not Charlton Heston —not yet— but John Charles Heston and, under this name, he attended New Trier High School at Winnetka, a northern suburb of Chicago. There he might have met some students who later became famous, such as actor Rock Hudson (then still known as Roy Harold Scherer, Jr. [*]) and Nobel laureate Jack Steinberg (a physicist, donated his Nobel medal to New Trier High School). However, perhaps the three boys never met, because of their differences in age: Heston was born in 1923, "future Hudson" in 1925, and Steinberg in 1921. You know, two years may be seen as a generational barrier by teenagers, even (or especially) if attending the same school.
Rock Hudson and Jack Steinberger attended New Trier High SchoolHave a look at the New Trier High School's logo: it shows the Porta Nigra (Black Gate) built by the Romans around 180-200 AD in Augusta Treverorum —now Trier, Germany. The reason is that Winnetka is one of the villages in the New Trier Township, Illinois; the township was established in 1850, and its name was most likely chosen by a German settler. Trier claims to be the oldest city in Germany, founded in or before 16 BC. In addition to possessing a remarkable set of Roman and medieval buildings, Trier is known as the birthplace of philosopher Karl Marx (1818-1883).

But... am I digressing? Then, I will finish the explanation in a new post.


Image sources:
Heston as Moses in The Ten Commandments: Wikipedia.
Hudson, New Trier Highschool's logo, and Steinberger: Wikipedia (1, 2, 3).

[*] The name "Rock Hudson" is a combination of the Rock of Gibraltar and the Hudson River (!)


Clipart from Clipartheaven.comA year has passed since my first post on this blog.
Happy birthday, Twisted Bacteria!

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Mar 8, 2008

Women scientists, sixty years ago

Microscopic image (200-fold magnification) of Candida albicansNew York City, 1949. During the last three years, Elizabeth Hazen had been isolating hundreds of microbes from dirt samples taken at different locations. Many microbiologists at the time were following a path open by Alexander Fleming, Selman Waksman and others, who discovered that some soil microbes produced certain substances—antibiotics—with powerful activities against bacteria. However, rather than looking for a new agent against prokaryotic microbes, Elizabeth searched for a medicine to fight fungal infections. For this purpose, she grew the soil microbes and tested the cultures against disease-causing fungi (Cryptococcus neoformans, Candida albicans [see image]). Whenever a culture showed an interesting activity, she put it in a glass Mason jar and mailed it to Albany, 250-km away. Here, Rachel Brown—a chemist—used the culture for purification and characterization of the active compound. Then, Rachel mailed the fruit of her efforts back to New York, where the microbiologist tested the sample again for fungicidal potency. Through this collaboration, the two scientists isolated several antifungal compounds that, unfortunately, were too toxic when tested in laboratory animals.

Chemical structure of Nystatin A1But, finally, Elizabeth and Rachel found a useful fungicidal agent with a lower toxicity. It was produced by a soil bacterium isolated from a sample that Elizabeth had collected, while on holiday, in Warranton, Virginia. She had taken a bit of soil at the edge of a cow pasture, near a dairy barn, at the farm of a certain Walter B. Nourse. Because the microbe appeared to be a new species of streptomycetes, it received the name Streptomyces noursei, in honor of Mr. Nourse. The fungicidal agent was initially named fungicidin, but it was soon renamed nystatin, as both Elizabeth and Rachel worked for the New York State Department of Health (although in different locations). Since then, nystatin has been widely used to treat candidiasis and other fungal infections.


Related links:

This post modestly celebrates March 8th, International Women's Day. The discovery of nystatin seems a good example of an important contribution of women scientists to microbiology, natural product chemistry, and medicine. A related story is that of Alma Whiffen, who discovered cycloheximide—also known as actidione—around the same time (1947). She isolated the compound from cultures of a soil microbe, Streptomyces griseus. Cycloheximide has antifungal activity, and was employed to treat fungal infections in plants; however, it is not useful for human treatment. The compound is better known as a general inhibitor of protein synthesis in eukaryotes, and it is widely used for research purposes. Read more here:

More related links:

Image credits: Wikipedia.

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Jan 22, 2008

Petri Dish Circus

The following video (by MicrobeWorld, grabbed from SciVee) portrays an interview to Mary Resing, artistic director for Active Cultures, a theater company from Maryland, US. She talks about Petri Dish Circus, a play inspired by the extraordinary, classic book Microbe Hunters by Paul de Kruif. The video includes some excerpts from the actual performance.

(If video functioning is not smooth:
click on "pause", wait for a few minutes as the video gets fully loaded [indicated as a blue bar growing from left to right], then click on "play")




Links:

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Nov 26, 2007

Happy birthday, Microbiology!

According to Institut Pasteur (Lille, France):

"(...) 2007 is the year of the 150th anniversary of Microbiology, born in Lille on August 3rd 1857, when Louis Pasteur, then dean of the Science Faculty at the Lille University, presented his work on lactic acid fermentation at the Société des Sciences de Lille"
(So my congratulations arrive some months late)

I don't know how many people support such a defined birthday for Microbiology (do other sciences have birthdays?). Undoubtedly, Pasteur's work is a major milestone in the study of microbes, from both technical and conceptual points of view, but... was there no microbiology before Pasteur? (see links below)

Anyway, Institut Pasteur and we all have many reasons to celebrate the work of the great scientist, and the anniversary is being celebrated with conferences and other events. Among these, an international scientific symposium will be held at Lille on December 10th-12th, including sessions on Cellular Microbiology, Molecular Microbiology/Genomics, Host-pathogen interaction/immunity, and Virology.


Some links with basic notions on microbiology history:

In Spanish:

If you know other interesting websites on the history of Microbiology (in any language), you may share them with us by adding a comment to this post (click on "comments" below).

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Oct 3, 2007

The froth of the liquid jade

Thirteen centuries ago, Tibetans started to enjoy the drinking of tea. However, the tea plant (Camellia sinensis) did not grow on the Tibet plateau, so the product had to be brought from the neighbor regions of Sichuan and Yunnan (present southwest China). Around the year 1000, a large-scale commerce was already established: tea, sugar and salt came in exchange of horses, furs and other Tibetan goods. All these products were transported through a very mountainous terrain, with mules and horses following a path known as the Ancient Tea and Horse Caravan Road, or the Ancient Tea-Horse Road, which was heavily used until mid 20th century. Given the difficulties of the trip, merchants compressed the tea leaves as much as possible, so fewer horses were needed for the transport. With time, instead of loose leaves, tea started to be traded in the form of hard, dry cakes of various shapes, including tea bricks (which were used as tea money in several Asian regions).

A renowned area of tea production was Pu-Erh county, in Yunnan. Today, Pu-Erh tea (or just “pu-erh”) is generally compressed into cakes or bricks, and has become very appreciated among tea connoisseurs all over the world. Pu-erh is made from a “broad leaf” variety of Camellia sinensis (var. assamica), and the best tea is said to come from old wild trees growing in the Famous Tea Mountains. Many wild and cultivated trees, known as “Tea Tree Kings,” are more than a thousand years old. The traditional elaboration converts pu-erh into an unusual tea, because it can be stored for years and its quality improves with aging (if conditions are adequate). In other words, pu-erh is a “living” tea, which matures with age due to the activity of certain microorganisms. The custom of aging the tea is most likely reminiscent from the times of caravans, when tea cakes had to endure several months of transport across the mountains and were traded as highly valuable goods for years. Similarly to other teas, pu-erh might have some beneficial effects on human health: antioxidant, anticancer, and lowering cholesterol, blood pressure and blood sugar. Concerning its flavor, some experts say that it is “strongly earthy but clean, reminiscent of the smell of rich garden soil or an autumn leaf pile, sometimes with roasted or sweet undertones.”

ResearchBlogging.orgIn a less poetical tone, a group of researchers from Taiwan has studied the effect of microbial fermentation on the quality and chemical composition of pu-erh. First, they isolated a number of fungi and bacteria from two types of high-quality pu-ehr, which were 20-25 years old. They used these microbes to inoculate fresh tea leaves (previously sterilized), which were then fermented under controlled conditions for 7 months. Next, the teas were evaluated by a group of experts, assessing
flavor and quality. As a result, a number of bacterial strains, belonging to the Actinoplanes and Streptomyces genera, were found to contribute to pu-erh characteristic taste and flavor. The researchers observed that the fermentation of fresh tea leaves with some of the Streptomyces microbes produced a tea with at least some of the characteristics typical of aged pu-erh. The characteristics included color of tea infusion, antioxidant activity and content of several compounds (statins, GABA, polyphenols) that may be involved in the alleged health benefits of tea. These studies will contribute to a better understanding of the process of pu-erh aging, and eventually might lead to a controlled production of teas with healthier properties.


Reference:
Jeng, K., Chen, C., Fang, Y., Hou, R.C., Chen, Y. (2007). Effect of Microbial Fermentation on Content of Statin, GABA, and Polyphenols in Pu-Erh Tea. Journal of Agricultural and Food Chemistry, 55(21), 8787-8792. DOI: 10.1021/jf071629p



Link list:


****************************************************
This post is my contribution to Science Linked: Bacteria, a Group Writing Project at Science in Review.
****************************************************

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Jul 12, 2007

Romans, dried figs and Streptomyces

In the year 79 AD, the Roman towns of Herculaneum and Pompeii were devastated by a terrible eruption of Mount Vesuvius. As a result, the towns were buried under many meters of volcanic ash, which left buildings, food remains and human bodies in a remarkable state of preservation. This allows to study the state of health of ancient Romans and its relationship to nutrition and other environmental conditions. For instance, analysis of human remains from Herculaneum showed lesions typically produced by tuberculosis and, especially, brucellosis. The high frequency of brucellosis has been related to the eating of contaminated cheese: Herculaneum had an important production of goat's milk and cheese. Remarkably, the study of carbonized cheese showed particles of the right size and shape, suggesting that they were bacteria of the Brucella group.

However, the Herculaneum inhabitants appeared to suffer few non-specific infections, which were common in antiquity due to poor sanitary conditions. A recent study suggests that people were protected against these infections due to consumption of dried fruits contaminated by antibiotic-producing Streptomyces!

The author of the work arrived to this conclusion through two kinds of experimental evidences:

First, examination of food remains under the microscope (both light and scanning electron) revealed the presence of virus and possible Salmonella on eggshells, and Saccharomyces in wine and bread. More important for us was the observation, under the skin of pomegranate seeds and figs, of a dense net of branching filaments resembling those of Streptomyces. These fruits were originally dried as a mode of preservation: Romans buried them in straw under a weight to achieve dehydration. This technique may explain the proliferation of Streptomyces. And we all know that Streptomycetes are prolific producers of antibiotics, right?

Second, histological study of bone samples from human remains (using a confocal microscope) showed presence of auto-fluorescence with characteristics typical of tetracycline-labeled bone occurring during life. Tetracycline antibiotics mark human bone, as it has been established for both modern and ancient humans. An example of tetracycline-labeled human bones was previously described from a cemetery in Sudanese Nubia dated 350-550 AD; in this case, a possible source of tetracycline was the grain stored in mud containers, which provided a proper environment for proliferation of Streptomyces.

I found that the paper and the whole story (mixing archeology and microbiology together) are fascinating. Of course, I'd certainly appreciate more experimental evidence concerning unequivocal identification of tetracycline in bones (could the fluorescence be due to any other molecule with similar properties but different to tetracycline?). And I wonder how common is tetracycline production among Streptomycetes. It would be very nice if the hypothesized conditions could be replicated, i.e. grow some figs and pomegranates (Roman style = "organically" produced?), and dry them using the Roman technique (ideally in the Herculaneum region). Then, try to detect tetracycline in the fruits. You can even isolate some Streptomycetes from the dried fruits, and screen the isolates for tetracycline production...

Reference:
Capasso, L. (2007). Infectious diseases and eating habits at Herculaneum (1st century AD, southern Italy). International Journal of Osteoarchaeology, 17(4), 350-357. DOI: 10.1002/oa.906

[Sadly, the author uses the word "mould" for Streptomyces, which is a bacterium, not a fungus. This mistake can still be found in medical and other technical literature]

(Image: Mosaic on a wall in the House of Neptune and Amphitrite, in Herculaneum, Italy. Source: Wikipedia)



UPDATE (September 3, 2010):
A scientific article has been published confirming the presence of tetracycline in the Nubian bones! The reference is:
Mass spectroscopic characterization of tetracycline in the skeletal remains of an ancient population from Sudanese Nubia 350–550 CE
Am. J. Phys. Anthropol. (2010) 143, 151-154.
DOI: 10.1002/ajpa.21340
(Found via Biounalm: Los antibióticos se usaban desde hace 2000 años?)


UPDATE (September 10, 2010):
See other blogs (in Spanish): Los nubios ya usaban antibióticos hace 2.000 años (Amazings.es), Una pinta de tetraciclina (Curiosidades de la Microbiología).

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Jun 9, 2007

Time travel

You may know Google News Archive Search. I enjoy using it to search for old, historical stories. Soon I noticed that the oldest (free) stories came from the archives of Time Magazine, which are fully available for searching and reading (don't miss the covers!). Looking for articles containing the words "Streptomyces" or "actinomycete" in the complete Time archive, I got only five hits. Remarkably, they were written on 1948, 1949, 1950 and 1963. (So sad, it seems nothing related to these terms has happened in almost 50 years!)

The Time articles, which deal with the discovery of antibiotics from actinomycetes, are:

(*) Waksman was on the cover of this issue of Time magazine.

(Concerning the discovery of streptomycin, I very much recommend an article by Veronique Mistiaen: Time, and the great healer, The Guardian, Nov. 2, 2002)

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